Synonyms: PLCL, PLLA-PCL
Linear Formula: CH3(C6H10O2)m(C6H8O4)nCH3
CAS No.: 65408-67-5
● Product Description
PLCL is a biodegradable copolymer composed of L-lactide and ε-caprolactone. It combines tunable mechanical strength with controllable degradation rates, offering excellent flexibility and biocompatibility. These properties make it an ideal material for medical implants, tissue engineering scaffolds, and controlled drug delivery systems.
● Specifications
Appearance | White granules |
Melt Point: | ≈110-120 °C |
Density: | 1.0 - 1.28 g/cm³ at 25 °C |
Soluble in: | various organic solvents like hexafluoroisopropanol, dichloromethane, acetone, ethyl acetate, dimethylformamide Storage: -15°C, protected from light and moisture |
● Applications
SEM Image of PLCL Microspheres
SEM Images of Random PLCL Nanofibers
● Product List
Product Number | Monomer ratio | Inherent viscosity | Mn(g/mol) |
SorlymerTM PLCL 15 | L-lactide and ε-caprolactone (70:30) | 1.4-2.0 dl/g | 90,000 |
SorlymerTM PLCL 16 | L-lactide and ε-caprolactone (85:15) | 1.5-2.0 dl/g | 120,000 |
● References
1. Liu, F., Liao, X., Liu, C., et al. Poly(l-lactide-co-caprolactone)/tussah silk fibroin nanofiber vascular scaffolds with small diameter fabricated by core-spun electrospinning technology. J Mater Sci, 2020, 55, 7106–7119.
2. Nedjari, S., Awaja, F. & Altankov, G. Three Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response of Mesenchymal Stem Cells. Sci Rep, 2017, 7, 15947.
3. S Zhuang, X Jin, L Cen, Y Shao, Encapsulation of hydroxycamptothecin within porous and hollow poly(l-lactide-co-ε-caprolactone) microspheres as a floating delivery system for intravesical instillation. Biomater. Sci., 2024,12, 3659-3671.
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