Synonyms: Poly(lactic-co-glycolic acid)
Linear Formula: [(C6H8O4)x(C4H4O4)y]n
CAS No.: 30846-39-0
● Product Description
Poly(lactic-co-glycolic acid) (PLGA), a copolymer polymerized from lactic acid (LA) and glycolic acid (GA) monomers, is a biomedical polymer that integrates the advantages of polylactic acid and glycolic acid. The Food and Drug Administration (FDA) has approved PLGA for micro and nano particles and for a number of therapeutic devices such as grafts, sutures, implants and prosthetic devices.
Key advantages of PLGA include:
•tunable degradation rate (achievable by adjusting LA/GA ratio and molecular weight, enabling its use in controlled drug/protein delivery systems and tissue engineering scaffolds);
•versatile processability (e.g., extrusion, spinning, biaxial stretching) with diverse forms (microspheres, microcapsules, nanospheres, nanofibers);
● Specifications
Appearance | light yellow or colorless granules |
Density: | 1.2-1.3 g/cm³ at 25 °C |
Melt Point | 140-150℃ |
Soluble in | tetrahydrofuran, acetone, ethyl acetate and chlorinated solvents. |
Storage | -15°C, protected from light and moisture |
Applications
SEM Image of porous PLGA Microspheres
SEM Images of Random PLGA Nanofibers (Left) and Aligned PLGA Nanofibers (Right)
● Product List
Product Number | Monomer ratio | Inherent viscosity |
SorlymerTM PLGA 17 | lactide:glycolide (10:90) | 1.4-2.0 dl/g |
SorlymerTM PLGA 18 | lactide:glycolide (82:18) | 1.5-2.0 dl/g |
SorlymerTM PLGA 23 | lactide:glycolide (85:15) | 2.0-2.5 dl/g |
SorlymerTM PLGA 31 | lactide:glycolide (85:15) | 2.7-3.5 dl/g |
● References
[1] Su, Y. et al. PLGA-Based Biodegradable Microspheres in Drug Delivery: Recent Advances in Research and Application. Drug Delivery 2021, 28 (1), 1397–1418.
[2] Vlachopoulos, A., Karlioti, G. et al. Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances. Pharmaceutics 2022, 14 (2), 359.
[3] Dawei Ding, Qingdi Zhu, Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics, Materials Science and Engineering: C, 2018, 92, 1041-1060.
[4] Yu, CC., Chen, YW., Yeh, PY. et al. Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release. J Nanobiotechnol, 2019, 17: 31.
[5] Milosevic, Miljan; Stojanovic, Dusica; Simic, Vladimir; et al. A Computational Model for Drug Release from PLGA Implant. Materials, 2018, 11(12): 2416.
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