Confined impingement jet mixer

Product overview

Confined impingement jet mixer: High-Efficiency Nanoparticle Synthesis Reactor

Based on Flash Nanocomplexation technology, his mixer achieves millisecond-level high-efficiency mixing via the rapid collision of two or multiple jets in its microchamber. It leverages multiple intermolecular forces (electrostatic, coordination, hydrogen bond and hydrophobic interactions) to effectively promote the encapsulation of active ingredients, and form uniform, stable nanoparticles.

Applications

Core Uses

This mixer supports biomedical applications by:

Incorporating varied components (small-molecule drugs, macromolecules like nucleic acids/proteins/synthetic polymers, and imaging agents) into nanoparticles;

Compatible Nanoparticle Types

It facilitates large-scale manufacturing of:

•Organic nanoformulations and nanocarriers

•Inorganic nanoparticles

•Organic–inorganic hybrid nanoparticles

Case Study 

Formulation

Organic phase ：DSPC/Cholesterol （weight ratio:1:1）in ethanol

Aqueous phase：PBS (pH 7.2)

Effect of flow rate on the particle size and PDI of liposome particles

Technical Specification

References

1. H. Hu et al., Materials Today, (2020), https://doi.org/10.1016/j.mattod.2020.08.019

2. Santos, J. L., Mao, H.Q*. et al, Small. 2016, 12(45):6214–6222.

3. He, Z.Y., Mao, H.Q. et al,Biomaterials, 2017,130: 28–41.

4. Liu, Zhijia , et al. Nanoscale, 2019,11, 9410-9421.

5. Ke, X., Tang, H., & Mao, H.Q. International Journal of Pharmaceutics . 2019, 564: 273–280.