Vortex Mixer

Product overview

Vortex Mixer: High-Efficiency Nanoparticle Synthesis Reactor

(Flash Nanocomplexation Technology)

Core Advantages: Achieves rapid fluid mixing via tangential multi-jet introduction, enabling high-throughput production; leverages intermolecular forces (electrostatic/coordination/hydrogen bond/hydrophobic) to boost active ingredient encapsulation and ensure consistent, reproducible nanoparticles.

Features

Model Options:

▸ 2-inlet : 2 vertical inlets (relative to helical pipe/mixing chamber plane), paired-channel layout → ideal for dual-fluid mixing.

▸ 3-inlet : 3 distributed vertical inlets, multi-channel setup → optimized for triple-fluid blending.

▸ 4-inlet : 4 symmetric vertical inlets (2 opposing pairs), balanced arrangement → designed for 4-fluid simultaneous mixing.

✔ non-equal momentum mixers 

✔ High adaptability for multi-interactionally constructed ternary and quaternary nanoparticles

✔ high chemical resistance

✔ wide range of carrier materials

Applications

Core Uses

This mixer supports biomedical applications by:

Incorporating varied components (small-molecule drugs, macromolecules like nucleic acids/proteins/synthetic polymers, and imaging agents) into nanoparticles;

Compatible Nanoparticle Types

It facilitates large-scale manufacturing of:

•Organic nanoformulations and nanocarriers

•Inorganic nanoparticles

•Organic–inorganic hybrid nanoparticles

Case Study 1

Formulation

Volumetric flow rate（mL/min)

Effect of flow rate on the particle size and PDI of liposome particles, under a fixed flow rate ratio of 3:1

Case Study 2

Formulation

Fluid 1: Chitosan (CS) solution (1 mg/mL, pH 5.3)

Fluid 2: Sodium tripolyphosphate (TPP) solution (0.2 mg/mL, pH 7.6)

Fluid 3: Insulin solution (0.5 mg/mL, pH 2.8)

Fluid 4: Water

Effect of total flow rate on the particle size and PDI of drug-loaded polymer nanoparticles, under a flow rate ratio of 1:1:1:1

Technical Specification

References

1. H. Hu et al., Materials Today, (2020), https://doi.org/10.1016/j.mattod.2020.08.019

2. Santos, J. L., Mao, H.Q*. et al, Small. 2016, 12(45):6214–6222.

3. He, Z.Y., Mao, H.Q. et al,Biomaterials, 2017,130: 28–41.

4. Liu, Zhijia , et al. Nanoscale, 2019,11, 9410-9421.

5. Ke, X., Tang, H., & Mao, H.Q. International Journal of Pharmaceutics . 2019, 564: 273–280.